New insights to the brain functions of prolyl oligopeptidase
نویسندگان
چکیده
منابع مشابه
The natural product berberine is a human prolyl oligopeptidase inhibitor.
Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus. This peptidase has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders, and therefore may have important clinical implications. Among the strategies used to find novel prolyl oligopeptidase inhibitors, traditional Chinese m...
متن کاملMechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?
In the aging brain, the correct balance of neural transmission and its regulation is of particular significance, and neuropeptides have a significant role. Prolyl oligopeptidase (PREP) is a protein highly expressed in brain, and evidence indicates that it is related to aging and in neurodegenration. Although PREP is regarded as a peptidase, the physiological substrates in the brain have not bee...
متن کاملProlyl Oligopeptidase An Unusual β-Propeller Domain Regulates Proteolysis
residues. One such enzyme is prolyl oligopeptidase (Ca-margo et al., 1979; Moriyama et al., 1988), previously called prolyl endopeptidase or postproline cleaving en-recently gained pharmaceutical interest, since specific United Kingdom inhibitors reverse scopolamine-induced amnesia in rats Its activity in plasma Coventry CV4 7AL correlates with different stages of depression (Maes et United Kin...
متن کاملThe Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis
Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its family members in many processes and different pathologies of the immune system. Most research has been focused on either DPPIV or just a few of its family members. It is, however, essential to consider the entire DPP family when discussing any one of its members. There is a substantial overlap between fam...
متن کاملStructure and localization of the mouse prolyl oligopeptidase gene.
We have cloned and characterized the genomic structure of the mouse gene for prolyl oligopeptidase that is mapped to chromosome 10B2-B3. The gene is about 92 kilobases in size and contains 15 exons. All exon-intron junction sequences conform to the GT/AG rule. Comparison with the presumed domain structures of the mouse prolyl oligopeptidase indicates that the propeller domain of the enzyme is e...
متن کامل